Although my Adwords activity has definitely been small scale in terms of spend over the past three years it's been pretty specific and I really don't think this is a real issue (I assume you are meaning concerns that running Adwords will damage organic results as it would be in Google's best interests to keep your presence a paid for one)
I find sites can rank very well for one specific keyword in the results but a bit of PPC is necessary for any presence in more general terms (this though is because of the site's newness, lack of general content and relatively low reach, few back links and greater number of search results you are competing against). The PPC activity has no negative effect on organic results for either the general or specific keyword to be honest.
I did worry for a while when I had one site that had been sitting on Yahoo and MSN frontpage, often in #1, for about six months when it languished at #150 or below on Google for the same keyword, and it was a site that had been promoted from it's first day via Adwords. As I padded the site out (and gave it a bit more frequent attention for updating) it's risen to the frontpage with the recent Google results. This happened after I'd stopped PPC activity on it for a while, but I think the trend was most certainly there already.
I wouldn't be overly bothered about these kind of rumouors of a negative effect on organic results. They seem to have been floating around since the start of Adwords. I've always been more worried about the poor quality of some of the ads on the content network. 30 cents for a blind monkey in Timbuktu clicking an ad on some scraper site is not going to be much use at all. If you do anything with Adwords my choices would still be search results but I have used and found site targeted CPM ads can be useful too.
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