All my sites hosted by 1and1.co.uk seem to be offline. 1&1 Internet Ltd. itself also seems to be offline, I can get 1and1.com but that is not for uk customers. I tried calling support line and all I get is all our support lines are busy please call back later Goodbye!
There is a major european router down at the moment. It is certainly stopping Virgin Media customers from accessing lots of servers across europe, and may be impacting other ISPs.